منابع مشابه
Christmas factor (IX) defect in a case of haemorrhagic thrombocythaemia.
The mechanism of bleeding in haemorrhagic thrombocythaemia is obscure. Although by definition there is always a raised platelet count, the haemorrhagic episodes cannot be satisfactorily correlated with the level of the count. In fact, thrombocythaemia can exist without bleeding manifestations (Fanger, Cella, and Litchman, 1954). The most commonly occurring laboratory defect is an abnormal bleed...
متن کاملHaemophilia B (Factor IX Deficiency)
If a woman is a carrier there is a 1 in 2 chance that any son will be affected and a 1 in 2 chance that any daughter will be a carrier. If a man with the disease fathers a child, any daughter will be a carrier and any son will be unaffected and will not carry the gene. There is a report of a daughter of a man with the disease who had a factor IX level of 5% and haemarthroses and this was though...
متن کاملAn investigation of three patients with Christmas disease due to an abnormal type of factor IX.
Three patients with Christmas disease whose plasma was shown to have a prolonged one-stage prothrombin time with ox brain thromboplastin have been investigated. These patients have an inhibitor for the reaction between factor X, factor VII, and ox brain extract. The abnormal constituent responsible for this inhibitor appears to be factor IX whuch is functionally inactive but antigenically indis...
متن کاملA comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor).
A comparison has been made of the electrophoretic behavior, chemical composition, amino-terminal sequence, and immunological properties of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Some immunological crossreactivity was found between the antibody to prothrombin and factor X although prothrombin and factor X differ substantially in amino-acid and carbohydrat...
متن کاملImmunoaffinity purification of factor IX (Christmas factor) by using conformation-specific antibodies directed against the factor IX-metal complex.
Factor IX is a vitamin K-dependent blood clotting zymogen that is functionally defective or absent in patients with hemophilia B. A method of immunoaffinity chromatography has been developed for a one-step high yield purification of factor IX directly from plasma. The technique utilizes conformation-specific antibodies that bind solely to the metal-stabilized factor IX conformer, but not to the...
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ژورنال
عنوان ژورنال: Medical Journal Armed Forces India
سال: 2012
ISSN: 0377-1237
DOI: 10.1016/j.mjafi.2011.12.007